Integrative Bioinformatics Analysis Reveals That Infarct-Mediated Overexpression of Potential miR-662/CREB1 Pathway-Induced Neuropeptide VIP Is Associated with the Risk of Atrial Fibrillation: A Correlation Analysis between Myocardial Electrophysiology and Neuroendocrine

<div>Protein interaction networks and drug prediction analysis. (a) Network showing the regulatory relationship between DEmiRNAs and DEmRNAs in AF. Red boxes show the constructed miRNA–TF–mRNA regulatory axis for CREB1 and VIP. (b) Sankey diagram showing predicted drugs that target CREB1 and VIP. (c) The motif of CREB1. (d) Differential expression of CREB1 and VIP in AF and SR. (e) Correlation analysis of VIP and CREB1. (f) Probability of CREB1 and VIP to predict the occurrence of AF. (g) Reliability of the joint CREB1 and VIP prediction model.</div>

Disease Markers

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Figure 2: Integrative Bioinformatics Analysis Reveals That Infarct-Mediated Overexpression of Potential miR-662/CREB1 Pathway-Induced Neuropeptide VIP Is Associated with the Risk of Atrial Fibrillation: A Correlation Analysis between Myocardial Electrophysiology and Neuroendocrine 

Figure 2 | Integrative Bioinformatics Analysis Reveals That Infarct-Mediated Overexpression of Potential miR-662/CREB1 Pathway-Induced Neuropeptide VIP Is Associated with the Risk of Atrial Fibrillation: A Correlation Analysis between Myocardial Electrophysiology and Neuroendocrine 