circRNA hsa_circ_0005909 Predicts Poor Prognosis and Promotes the Growth, Metastasis, and Drug Resistance of Non-Small-Cell Lung Cancer via the miRNA-338-3p/SOX4 Pathway

Figure 2

The function of circ_0005909 knockdown on tumor biological behaviors. (a) RT-PCR determined the levels of circ_0005909 in NSCLC cells transfected with sh-circ_0005909 or sh-NC. (b) CCK-8 assays after circ_0005909 knockdown. (c, d) The effects of ADM treatments on the inhibition of A549 and H460 cells. (e, f) Colony formation assays and EdU assays were performed to detect cell proliferation. (g) Tumors from the sh-NC or sh-circ_0005909 group are shown. (h, i) Volume and weight of tumors obtained from the sh-NC or sh-circ_0005909 group are displayed. (j) Transwell assays of NSCLC cells transfected with sh-circ_0005909 or sh-NC ( and ).

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