A Risk Score Model Based on Nine Differentially Methylated mRNAs for Predicting Prognosis of Patients with Clear Cell Renal Cell Carcinoma

Table 4

Uni- and multivariable Cox regression analyses in the training set.

Clinical characteristics	Training set ()	Univariable Cox			Multivariable Cox
		HR	95% CI	value	HR	95% CI	value
Age (years, )		1.777	1.171-2.697		1.352	0.846-2.158
Gender (male/female)	200/106	1.141	0.746-1.743		-	-	-
Neoplasm histologic grade (G1/G2/G3/G4/-)	7/130/118/47/4	2.783	2.088-3.710		1.470	1.076-2.009
Pathologic M (M0/M1/-)	229/52/25	4.720	3.115-7.153		1.034	0.403- 2.657
Pathologic N (N0/N1/-)	130/9/167	2.617	1.030-6.651		0.462	0.0985-2.171
Pathologic T (T1/T2/T3/T4)	151/40/107/8	2.101	1.678-2.630		0.753	0.456-1.243
Pathologic stage (I/II/III/IV)	148/30/73/55	2.135	1.774-2.568		1.989	1.101-3.592
Hemoglobin (elevated/low/normal/-)	5/151/104/46	0.423	0.276-0.646		0.466	0.269-1.087
Platelet qualitative (elevated/low/normal/-)	18/32/202/54	0.568	0.425-0.759		0.690	0.501- 0.949
White cell count (elevated/low/normal/-)	84/4/161/57	1.156	0.910-1.468		-	-	-
Serum calcium (elevated/low/normal/-)	5/112/90/99	1.017	0.658-1.570		-	-	-
Methylation RS model (high/low)	153/153	4.713	2.898-.665		2.574	1.149-5.767
Vital status (dead/alive)	97/209	-	-	-	-	-	-
Overall survival time (months, )		-	-	-	-	-	-