Research Article
The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis
Table 1
Association between perineural invasion (PNI) and other clinicopathological factors.
| | PNI- (%) | PNI+ (%) | value |
| | Nationality | | | <0.001 | | Chinese | 428 (22.4) | 20 (1.9) | | | Korean | 1486 (77.6) | 1035 (98.1) | | | Gender | | | 0.055 | | Male | 1311 (68.5) | 686 (65.0) | | | Female | 603 (31.5) | 369 (35.0) | | | Age | | | 0.028 | | <60 | 1011 (52.8) | 602 (57.1) | | | ≥60 | 903 (47.2) | 453 (42.9) | | | Tumor location | | | <0.001 | | Upper third | 303 (15.8) | 192 (18.2) | | | Middle third | 412 (21.5) | 313 (29.7) | | | Lower third | 1194 (62.4) | 545 (51.7) | | | Whole stomach | 5 (0.3) | 5 (0.5) | | | Tumor size | | | <0.001 | | ≤2 cm | 531 (27.7) | 75 (7.1) | | | 2.1-5 cm | 953 (49.8) | 521 (49.4) | | | 5.1-8 cm | 339 (17.7) | 334 (31.7) | | | >8 cm | 91 (4.8) | 125 (11.8) | | | Differentiation of tumor | | | <0.001 | | Well | 155 (8.1) | 33 (3.1) | | | Moderate | 576 (30.1) | 236 (22.4) | | | Poor | 1183 (61.8) | 786 (74.5) | | | pT stage | | | <0.001 | | T1 | 779 (40.7) | 18 (1.7) | | | T2 | 405 (21.2) | 103 (9.8) | | | T3 | 294 (15.4) | 286 (27.1) | | | T4a | 415 (21.7) | 636 (60.3) | | | T4b | 21 (1.1) | 12 (1.1) | | | pN stage | | | <0.001 | | N0 | 1084 (56.6) | 237 (22.5) | | | N1 | 298 (15.6) | 172 (16.4) | | | N2 | 257 (13.4) | 229 (21.7) | | | N3a | 199 (10.4) | 262 (24.8) | | | N3b | 76 (4.0) | 154 (14.6) | | | Staging | | | <0.001 | | Stage I | 953 (49.8) | 65 (6.1) | | | Stage II | 457 (23.9) | 271 (25.7) | | | Stage III | 504 (26.3) | 719 (68.2) | | | Lymphatic invasion | | | <0.001 | | Negative | 1470 (76.8) | 389 (36.9) | | | Positive | 444 (23.2) | 666 (63.1) | | | Vascular invasion | | | <0.001 | | Negative | 1500 (78.4) | 371 (35.2) | | | Positive | 414 (21.6) | 684 (64.8) | | | Chemotherapy | | | <0.001 | | No | 1277 (66.7) | 269 (25.5) | | | Yes | 637 (33.3) | 786 (74.5) | |
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