The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis

Table 2

Univariate and multivariate analyses of the prognostic factors in patients with stage III tumors.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age		<0.001		<0.001
<60	1		1
≥60	1.39 (1.18-1.63)		1.45 (1.23-1.71)
Tumor location		0.008		0.047
Upper third	1		1
Middle third	0.89 (0.70-1.14)		0.87 (0.68-1.11)
Lower third	0.93 (0.76-1.51)		0.95 (0.77-1.18)
Whole stomach	3.63 (1.60-8.25)		2.75 (1.18-6.38)
Tumor size		<0.001		0.18
≤2cm	1		1
2.1-5cm	0.96 (0.60-1.53)		0.86 (0.53-1.39)
5.1-8cm	1.39 (0.87-2.22)		1.01 (0.62-1.64)
>8cm	1.80 (1.11-2.94)		1.10 (0.66-1.84)
Differentiation of tumor		0.03		0.468
Well	1		1
Moderate	1.35 (0.66-2.75)		1.18 (0.58-2.43)
Poor	1.70 (0.85-3.43)		1.32 (0.65-2.67)
pT stage		<0.001		<0.001
T1	1		1
T2	0.68 (0.21-2.23)		0.86 (0.25-2.94)
T3	0.45 (0.14-1.43)		0.74 (0.22-2.45)
T4a	0.76 (0.25-2.38)		1.27 (0.39-4.15)
T4b	2.08 (0.63-6.85)		3.43 (0.99-11.91)
pN stage		<0.001		<0.001
N0	1		1
N1	0.63 (0.87-4.60)		1.25 (0.17-9.51)
N2	0.93 (1.30-6.65)		2.21 (0.30-16.54)
N3a	1.58 (0.22-11.32)		3.59 (0.48-26.78)
N3b	2.94 (0.41-21.00)		6.60 (0.88-49.31)
Vascular invasion	1.16 (0.98-1.37)	0.08
Lymphatic invasion	1.17 (0.99-1.38)	0.07
Chemotherapy		0.001		<0.001
No	1		1
Yes	0.73 (0.61-0.88)		0.67 (0.55-0.81)
Perineural invasion		0.032		0.037
Negative	1		1
Positive	1.20 (1.02-1.42)		1.21 (1.01-1.44)
Country		0.38
Korea	1
China	1.09 (0.90-1.33)