Clinical Significance of Procalcitonin, C-Reactive Protein, and Interleukin-6 in Helping Guide the Antibiotic Use for Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Table 3

Prediction of PCT, CRP, and IL-6 levels in AECOPD patients with antibiotic replacement therapy.

Variables	No-changed	%	Changed	%	value	B	S.E.	Wald		OR	OR (95% CI)
	PCT (ng/mL)														<0.001
CRP (mg/mL)					<0.001
IL-6 (pg/mL)					<0.001
PCT (ng/mL)
<0.25	191	94.1	43	70.5	<0.001			3.98	0.137
0.25-1	7	3.4	7	11.5	0.014	0.375	0.65	0.34	0.563	1.456	0.408-5.191
>1	5	2.5	11	18.0	<0.001	1.314	0.66	3.98	0.046	3.722	1.023-13.537
CRP (mg/mL)
<20	132	65.0	10	16.4	<0.001			20.24	<0.001
20-40	31	15.3	16	26.2	<0.001	1.935	0.45	18.47	<0.001	6.923	2.864-16.732
>40	40	19.7	35	57.4	<0.001	1.808	0.63	8.19	0.004	6.097	1.768-21.023
IL-6 (pg/mL)
<60	174	85.7	31	50.8	<0.001
≥60	29	14.3	30	49.2	<0.001	0.413	0.65	0.4	0.527	1.511	0.421-5.432
Constant						-2.596	0.33	62.43	<0.001	0.075