Research Article
Prognostic Value of Soluble Suppression of Tumorigenicity 2 in Chronic Kidney Disease Patients: A Meta-Analysis
Table 1
Baseline characteristics of included studies.
| | Author year | Country | Study population | Subjects () | Male (%) | DM (%) | HTN (%) | CVD (%) | Age (year) | Follow-up (year) | ST2 (ng/mL) | End-point event |
| | Hammer 2015 | Germany | HD | 1196 | 54.0% | 100.0% | NA | NA | | 4.0 | 25.0 (median) | All-cause mortality
Total CVD events | | Obokata 2016 | Japan | HD | 423 | 68.8% | 46.6% | 84.6% | 16.5% | | | 0.3 (median) | All-cause mortality
Total CVD events | | Zhang 2017 | China | HD | 414 | 61.6% | 22.9% | 94.0% | 9.2% | 61.8 (median) | 1.9 (median) | 26.9 (median) | All-cause mortality
CVD mortality | | Gungor 2017 | Turkey | Predialysis
CKD | 228 | NA | 26.3% | 23.7% | 18.9% | NA | 2.0 | NA | Total CVD events | | Keddis 2017 | US | Txp | 200 | 59.7% | 38.5% | 94.5% | 33.5% | 53.0 (median) | 2.3 (median) | 27.8 (median) | Total CVD events | | Tuegel 2018 | US | Predialysis
CKD | 883 | 56.0% | 43.0% | 87.0% | 40.0% | | 3.1 (median) | NA | All-cause mortality
HF events
Total CVD events | | Homsak 2018 | Slovenia | HD | 123 | 58.5% | 36.6% | 91.0% | 26.0% | 66.0 (median) | 2.3 (median) | 28.0 (median) | All-cause mortality | | Seo 2018 | Korea | HD | 182 | 57.7% | 56.0% | 80.8% | 14.3% | NA | 1.7 (median) | | All-cause mortality
CVD mortality
Total CVD events | | Plawecki 2018 | France | Predialysis
CKD | 218 | 64.0% | NA | NA | NA | 68.3 (median) | 3.0 (median) | 29.5 (median) | Total CVD events | | Bansal 2019 | US | Predialysis
CKD | 3314 | 54.0% | 47.0% | NA | 26.0% | 57.5 (median) | 7.9 (median) | NA | HF events | | Lamprea-Montealegre 2019 | US | Predialysis
CKD | 3053 | 54.8% | 48.1% | NA | 28.0% | | 8.0 (median) | NA | AF events | | Feldreich 2019 | UK | HD | 183 | 45.0% | 25.0% | NA | 19.0% | | 2.6 (median) | NA | CVD mortality | | Choi 2020 | Korea | PD | 74 | 63.5% | 28.4% | NA | 13.5% | | 3.2 (median) | | CVD mortality
Total CVD events | | Devine 2020 | UK | Txp | 367 | 63.8% | 13.6% | 80.4% | 21.8% | 47.0 (median) | 16.2 (median) | 33.1 (median) | All-cause mortality
CVD mortality
Total CVD events | | Wang 2020 | China | HD | 205 | 61.0% | NA | NA | NA | 59 (median) | 3 | 16.0 (median) | All-cause mortality
CVD mortality |
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NA: not available; HD: hemodialysis; CKD: chronic kidney disease; HDF: hemodiafiltration; Txp: transplant patients; PD: peritoneal dialysis; CVD: cardiovascular disease; HF: heart failure; AF: atrial fibrillation; DM: diabetes mellitus.
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