OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

Figure 3

(a) Apoptosis rate of HepG2, HepG2-OATP1B11a, HepG2-OATP1B11b, and HepG2-OATP1B115 cells incubated with sorafenib (0-15 μM). After sorafenib treatment, the rate of apoptosis increased significantly in OATP1B1-HepG2 cells compared to that in the control group. Gene mutations also affected the rate of apoptosis of HepG2 cells. (b) Cell viability of HepG2, HepG2-OATP1B11a, HepG2-OATP1B11b, and HepG2-OATP1B115 cells incubated with sorafenib (0-15 μM). Cell viability in HepG2-OATP1B11a, HepG2-OATP1B11b, and HepG2-OATP1B115 cells was significantly decreased compared with HepG2 cells (), and we found that the cell viability was higher in OATP1B11b or 15-HepG2 cells than in OATP1B11a-HepG2 cells after sorafenib treatments. .

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