Research Article

OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

Figure 4

Protein and mRNA expression levels of OATP1B1 and PXR in HepG2 cells following transfection with miR-148a mimics. Compared to control cells, OATP1B1 expression is significantly lower in transfected cells ( vs. ) (a). Similar to protein expression, mRNA levels of OATP1B1 are significantly lower in transfected cells ( vs. ) (c). Expression of PXR proteins in HepG2 cells is significantly lower after transfection with miR-148a mimics ( vs. ) (b). mRNA levels of PXR are also significantly lower than in control cells ( vs. ) (d). NC: control. ; .
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