OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

Figure 5

miR-148a affected the uptake of sorafenib in HepG2 cells incubated for different time (30-120 min) with varying concentrations of sorafenib (5-15 μmol/L). Bars represent the () of sorafenib uptake in control and transfected HepG2 cells incubated with different concentrations of sorafenib (5, 10, and 15 μM) for 30, 60, and 120 min, respectively. Intake of sorafenib increased significantly with concentration increasing in both groups of cells. Transfection with miR-148a mimics significantly affects the uptake of sorafenib in HepG2 cells (; ). However, incubation time has no apparent effect on the uptake of sorafenib in control and transfected HepG2 cells. ; .