OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

<div>Histopathological observations of peritumoral tissues. Vascular endothelial growth factor (VEGF) levels and microvessel density (MVD) in peritumoral tissues of rats in the control and experimental groups after immunohistological staining and treatment with 50 mg/kg sorafenib for 20 days. VEGF expression and MVD counts in the experimental group were significantly lower than those in the control group (not treated with PCN). VEGF positive rate and MVD count in tumor-adjacent tissues were also significantly decreased in the experimental group (<svg height="8.85534pt" id="M217" style="vertical-align:-0.4673595pt" version="1.1" viewbox="-0.0498162 -8.38798 66.9656 8.85534" width="66.9656pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 295 608C189 570 37 457 37 238C37 84 125 -12 242 -12C362 -12 447 89 447 209C447 311 374 393 267 393C247 393 226 386 204 376L137 343ZM227 337C318 337 361 256 361 173C361 105 336 22 258 22C176 22 126 120 126 240C126 266 127 291 132 310C155 323 189 337 227 337Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.204,0)"><path d="M285 378C315 398 338 416 353 432C373 451 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Symbols represent rat models of hepatocellular carcinoma untreated (-) or treated (+) with PCN.</div>

Disease Markers

fig9

Figure 9

Figure 9: OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma 