OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma

Table 2

Pharmacokinetic parameters of sorafenib in rats after oral administration of sorafenib with or without PCN.

Parameters	(-) PCN treatment	(+) PCN treatment
Kα (h^-1)
α (h^-1)
β (h^-1)
Tka (h)
Tα (h)
Tβ (h)
AUC (μg/mL/h)

(+) PCN treatment: sorafenib (50 mg/kg) was administered orally with PCN treatment (75 mg/kg); (-) PCN treatment: sorafenib (50 mg/kg) was administered orally without PCN treatment (75 mg/kg); Kα (h^-1): absorption rate constant; α (h^-1): distribution rate constant; β (h^-1): elimination rate constant; Tka (h): absorption half-life; Tα: distribution half-life; Tβ (h): elimination half-life; AUC (μg/mL/h): area under concentration-time curve. ( compared with (-) PCN treatment).