Clinical Utility of Serum Holotranscobalamin Measurements in Patients with First-Ever Ischemic Stroke

Table 4

Association of metabolic variables with serum homocysteine levels and NIHSS by multiple linear regression analyses in 130 patients with first-ever ischemic stroke.

Variables	Homocysteine (μmol/L)			NIHSS
	(SE)	Partial		(SE)	Partial
holoTC (pmol/L)	-0.107 (0.054)	-0.165	0.048	-0.830 (0.156)	-0.405	<0.01
Total vitamin B12 (pg/mL)	—	—	—	—	—	—
holoTC/total vitamin B12 (%)^,†	—	—	—	-0.631 (0.233)	-0.207	<0.01
Homocysteine (μmol/L)				—	—	—
Hemoglobin A1c (%)	—	—	—	—	—	—
Fasting glucose (mg/dL)	—	—	—	0.532 (0.223)	0.182	0.019
Triglyceride (mg/dL)	—	—	—	—	—	—
LDL cholesterol (mg/dL)	—	—	—	—	—	—
Total cholesterol (mg/dL)	0.004 (0.001)	0.179	0.040	—	—	—
BMI (kg/m^2)	—	—	—	0.022 (0.011)	0.158	0.041
Age (years)	—	—	—	0.006 (0.003)	0.146	0.049

Abbreviations: SE: standard error; holoTC: holotranscobalamin; LDL: low-density lipoprotein; BMI: body mass index. Log-transformed values were used for analysis. ^†Calculated after unifying the units for total vitamin B12 and holotranscobalamin.