Clinical Utility of Serum Holotranscobalamin Measurements in Patients with First-Ever Ischemic Stroke
Table 5
Holotranscobalamin (holoTC), total vitamin B12, homocysteine, glucose markers, lipids levels, and body mass index according to the National Institute of Health Stroke Scale (NIHSS).
NIHSS
Kruskal–Wallis grouping†
0 ()
1–4 ()
5–15 ()
16–20 ()
21–42 ()
holoTC (pmol/L)
143.7‡ [73.0–184.8]
127.0 [102.8–196.5]
118 [77.2–178.8]
141 [117–156]
58.1 [32.0–62.4]
0.04
a/b/b/a/c
Total vitamin B12 (pg/mL)
496.5 [280.0–679.5]
558 [440–819.3]
480 [299.0–756.0]
393 [277–566]
194 [162–290]
<0.01
a/b/a/c/d
holoTC/total vitamin B12 (%)§
34.0 [30.8–41.9]
30.6 [24.7–38.4]
34.5 [30.4–42.4]
43.7 [26.1–62.2]
29.5 [27.9–48.0]
0.143
Homocysteine (μmol/L)
11.7 [9.7–13.3]
12.6 [10.8–14.7]
12.8 [9.7–14.4]
13 [11.0–15.8]
10.9 [10.4–11.2]
0.26
—
Hemoglobin A1c (%)
5.5 [2.3–5.7]
5.9 [5.5–6.9]
6.3 [5.6–7.4]
6 [5.5–6.0]
5.5 [5.0–6.2]
0.02
a/b/b/b/a
Fasting glucose (mg/dL)
100.0 [92.3–110.0]
109.0 [94–135.8]
112.0 [99.0–159.0]
130 [112.0–147.8]
189.5 [156.5–209.0]
0.04
a/a/a/a/b
Triglyceride (mg/dL)
81 [54.0–107.5]
116 [79.0–171.0]
101.0 [52.0–129.0]
102 [53.5–160.5]
108.5 [69.8–145.8]
0.11
—
LDL cholesterol (mg/dL)
‡
0.71
—
Total cholesterol (mg/dL)
0.64
—
BMI (kg/m2)
0.57
—
Abbreviations: LDL: low-density lipoprotein; BMI: body mass index. Calculated from the one-way analysis of variance or the Kruskal–Wallis test, according to data distribution. †The same letters indicate the nonsignificant difference between groups based on the Mann–Whitney test. ‡Data are displayed as “median [Q1–Q3]” or “” according to their distribution. §‡Calculated after unifying the units for total vitamin B12 and holotranscobalamin.
