Analysis of Glomerular IgG Subclasses Switch in Idiopathic Membranous Nephropathy Classified by Glomerular Phospholipase A2 Receptor Antigen and Serum Antibody

Table 4

Predominance/codominance and EM stage in PLA2R-related and PLA2R-unrelated subgroup.

IgG subclass	Pathological stage				values
	(%) predominance or codominance				Chi-square test	Linear-by-linear association test
PLA2R-related	I ()	II ()	III ()	IV ()
IgG1	12 (39%)	37 (50%)	5 (42%)	7 (47%)	0.767	0.768
IgG2	1 (3%)	6 (8%)	0 (0%)	2 (13%)	0.493	0.434
IgG3	11 (35%)	14 (13%)	1 (8%)	1 (7%)	0.087	0.013
IgG4	30 (97%)	70 (95%)	12 (100%)	13 (87%)	0.469	0.380
PLA2R-unrelated	I ()	II ()	III ()	IV ()
IgG1	3 (43%)	5 (50%)	1 (25%)	3 (75%)	0.640	0.574
IgG2	0 (0%)	0 (0%)	0 (0%)	0 (0%)	NA	NA
IgG3	3 (43%)	1 (10%)	3 (75%)	1 (25%)	0.081	1.000
IgG4	4 (57%)	9 (90%)	3 (75%)	2 (50%)	0.331	0.835

NA: not available.