Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease

Table 2

Meta-analysis of miRNA-SNPs with autoimmune diseases.

Subgroup	No of studies	No of case/control	Allele model			Dominant model			Recessive model			Model
			OR (95% CI)			OR (95% CI)			OR (95% CI)
miR-146a rs2910164 (associated allele vs. reference allele: G vs. C)
All diseases
Overall	70	20034/28161	1.08 (1.01-1.15)	0.019	<0.001	1.09 (1.01-1.20)	0.049	<0.001	1.09 (0.99-1.19)	0.077	<0.001	R
AITD	3	1103/2322	1.03 (0.93-1.15)	0.57	0.147	1.13 (0.96-1.33)	0.153	0.563	0.94 (0.78-1.13)	0.522	0.171	F
Arthritis	23	5252/6454	1.15 (1.01-1.31)	0.034	<0.001	1.11 (0.95-1.29)	0.158	0.066	1.17 (1.01-1.36)	0.048	0.001	R
Asthma	4	1086/1420	1.16 (1.03-1.31)	0.014	0.314	1.25 (1.02-1.54)	0.029	0.165	1.20 (0.99-1.45)	0.067	0.784	F
SLE	6	2226/3011	1.12 (0.91-1.38)	0.275	0.001	1.15 (0.75-1.76)	0.45	0.002	1.09 (0.86-1.37)	0.49	0.033	R
Uveitis	8	2525/4595	1.44 (1.14-1.81)	0.002	<0.001	1.26 (1.13-1.40)	<0.001	<0.001	1.73 (1.21-2.47)	0.003	<0.001	R
IBD	8	1559/2522	0.79 (0.65-0.97)	0.027	<0.001	0.78 (0.65-0.92)	0.001	0.37	0.67 (0.50-0.88)	0.005	0.015	R
IgA	2	549/890	0.93 (0.62-1.41)	0.733	0.024	0.79 (0.50-1.24)	0.304	0.082	1.16 (0.47-2.87)	0.752	0.015	R
KD	2	652/742	0.96 (0.82-1.12)	0.596	0.536	0.96 (0.77-1.19)	0.707	0.457	0.93 (0.69-1.25)	0.606	0.882	F
Sclerosis	6	1265/1569	1.04 (0.76-1.42)	0.825	<0.001	1.14 (0.68-1.92)	0.613	0.006	0.96 (0.68-1.36)	0.803	0.011	R
Polymyositis	1	44/107	1.29 (0.76-2.21)	0.350	—	1.76 (0.85-3.65)	0.129	—	0.34 (0.02-6.63)	0.473	—	—
Psoriasis	4	2701/3224	1.15 (1.05-1.25)	0.001	0.269	1.38 (1.13-1.69)	0.002	0.802	1.10 (0.97-1.24)	0.138	0.147	F
T1DM	3	1045/1443	1.09 (0.72-1.64)	0.687	<0.001	1.07 (0.58-1.94)	0.838	0.027	1.12 (0.69-1.82)	0.638	<0.001	R
Ethnicity
East Asian	29	9164/13636	1.04 (0.96-1.13)	0.353	<0.001	1.04 (0.93-1.16)	0.511	<0.001	1.06 (0.93-1.20)	0.364	<0.001	R
Hispanic	8	2503/3671	1.03 (0.89-1.20)	0.677	0.001	1.05 (0.78-1.41)	0.744	0.012	1.05 (0.88-1.25)	0.576	0.008	R
Middle East	13	1301/1902	1.66 (1.35-2.04)	<0.001	<0.001	2.54 (1.60-4.02)	<0.001	0.015	2.13 (1.54-2.95)	<0.001	<0.001	R
Caucasian	19	6647/8129	0.95 (0.85-1.07)	0.383	<0.001	0.96 (0.83-1.10)	0.539	0.183	0.86 (0.75-0.99)	0.036	0.002	R
Oceanian	1	419/823	0.83 (0.68-1.00)	0.052	—	0.85 (0.52-1.41)	0.535	—	0.78 (0.61-0.99)	0.037	—	—
miR-196a2 rs11614913 (associated allele vs. reference allele: T vs. C)
All diseases
Overall	26	6555/10237	0.92 (0.88-0.97)	0.001	0.004	0.92 (0.86-0.98)	0.017	0.002	0.87 (0.81-0.95)	0.002	0.046	F
AITD	1	80/486	1.08 (0.77-1.51)	0.677	—	1.11 (0.68-1.82)	0.675	—	1.08 (0.57-2.06)	0.814	—	—
Arthritis	2	507/686	0.99 (0.83-1.18)	0.905	0.3	1.09 (0.86-1.39)	0.454	0.574	0.6 (0.21-1.72)	0.344	0.09	F
Asthma	4	757/980	0.92 (0.80-1.06)	0.249	0.763	0.92 (0.73-1.16)	0.482	0.965	0.84 (0.65-1.09)	0.198	0.518	F
SLE	1	405/486	0.98 (0.81-1.19)	0.831	—	0.97 (0.74-1.27)	0.801	—	0.98 (0.68-1.43)	0.946	—	—
Uveitis	4	1583/2705	0.80 (0.73-0.87)	<0.001	0.661	0.74 (0.64-0.84)	<0.001	0.688	0.74 (0.62-0.87)	<0.001	0.852	F
IBD	9	1948/2906	0.99 (0.88-1.13)	0.97	0.031	1.01 (0.79-1.27)	0.984	0.001	0.98 (0.84-1.12)	0.656	0.18	R
IgA	1	404/711	0.88 (0.74-1.05)	0.151	—	0.78 (0.57-1.06)	0.106	—	0.9 (0.69-1.17)	0.428	—	—
KD	1	531/623	0.94 (0.80-1.11)	0.489	—	0.99 (0.77-1.28)	0.928	—	0.86 (0.64-1.13)	0.277	—	—
Sclerosis	2	190/504	0.93 (0.72-1.21)	0.6	0.18	1.01 (0.71-1.44)	0.95	0.35	0.69 (0.38-1.25)	0.22	0.125	F
T1DM	1	150/150	1.56 (1.12-2.19)	0.009	—	1.39 (0.88-2.19)	0.163	—	2.64 (1.37-5.09)	0.004	—	—
Ethnicity
East Asian	12	3899/6447	0.89 (0.84-0.94)	<0.001	0.014	0.87 (0.79-0.96)	0.003	<0.001	0.84 (0.76-0.93)	0.001	0.344	R
Hispanic	3	897/1458	1.02 (0.89-1.15)	0.81	0.87	1.06 (0.88-1.26)	0.551	0.688	0.96 (0.75-1.22)	0.733	0.864	F
Middle East	6	746/958	1.03 (0.89-1.19)	0.652	0.102	1.04 (0.84-1.27)	0.744	0.675	1.01 (0.62-1.65)	0.963	0.022	F
Caucasian	5	1013/1374	0.92 (0.77-1.1)	0.365	0.075	0.89 (0.76-1.06)	0.211	0.314	0.87 (0.58-1.31)	0.502	0.062	R
miR-499 rs3746444 (associated allele vs. reference allele: C vs. T)
All diseases
Overall	35	8052/12084	1.16 (1.03-1.29)	0.011	<0.001	1.16 (1.09-1.24)	<0.001	<0.001	1.47 (1.3-1.66)	<0.001	<0.001	R
AITD	3	1106/2302	1.16 (0.99-1.34)	0.052	0.923	1.24 (1.04-1.47)	0.015	0.997	0.95 (0.61-1.46)	0.802	0.141	F
Arthritis	12	2075/2933	1.29 (1.15-1.44)	<0.001	<0.001	1.24 (1.09-1.42)	0.001	<0.001	1.54 (1.23-1.92)	<0.001	0.318	R
Asthma	5	1479/1830	1.56 (1.36-1.77)	<0.001	<0.001	1.48 (1.26-1.74)	<0.001	<0.001	2.8 (2.03-3.88)	<0.001	<0.001	R
SLE	3	670/932	1.25 (0.96-1.62)	1.101	0.327	1.31 (0.98-1.73)	0.064	0.328	1.44 (1.01-2.05)	0.044	0.492	F
Uveitis	4	1109/1345	0.83 (0.72-0.97)	0.017	0.089	0.85 (0.71-1.02)	0.089	0.228	0.59 (0.39-0.89)	0.012	0.249	R
IBD	7	1503/2318	1.11 (0.99-1.24)	0.073	0.547	1.02 (0.83-1.25)	0.88	0.053	1.18 (0.65-2.15)	0.594	<0.001	F
Sclerosis	1	110/424	1.15 (0.79-1.67)	0.461	—	1.19 (0.77-1.83)	0.435	—	1.16 (0.31-4.29)	0.823	—	—
Ethnicity
East Asian	18	5252/7856	1.07 (0.99-1.14)	0.079	0.241	1.03 (0.92-1.16)	0.622	0.012	0.98 (0.67-1.43)	0.916	0.001	R
Hispanic	3	900/1458	1.29 (1.02-1.63)	0.034	0.818	1.31 (1.02-1.68)	0.032	0.71	1.31 (1.02-1.68)	0.034	0.629	F
Middle East	11	1332/1984	1.62 (1.45-1.81)	<0.001	<0.001	1.69 (1.44-1.99)	<0.001	<0.001	2.03 (1.66-2.48)	<0.001	<0.001	R
Caucasian	3	568/786	1.03 (0.85-1.25)	0.729	0.788	1.11 (0.88-1.40)	0.376	0.87	0.77 (0.46-1.29)	0.316	0.784	F