Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients

Table 4

Univariate analysis of overall survival.

Variable	Mean OS months (95% CI)	value
Gender		0.127
-Male	22.73 (16.09-29.38)
-Female	39.38 (26.62-52.13)
Age at initial diagnosis		0.162
->50 years	28.74 (20.92-36.55)
-≤50 years	34.58 (21.92-47.24)
Tumor location		0.410
-Cardia	26.27 (14.77-37.76)
-Noncardia	32.03 (23.64-40.43)
Tumor cells differentiation		0.066
-Poor	26.49 (14.91-38.06)
-Well/moderate	32.08 (23.86-40.33)
Lauren classification		0.014
-Intestinal	33.09 (24.95-41.23)
-Diffuse/mixed	22.19 (11.04-33.34)
History of gastrectomy		0.030
-Absent	33.51 (25.82-41.19)
-Present	8.59 (2.98-14.19)
History of gastric ulcer		0.003
-Absent	32.26 (24.87-39.64)
-Present	3.67 (2.34-5.00)
Smoking		0.674
-No	32.04 (23.67-40.41)
-Yes	23.21 (12.69-33.73)
HER2 immunostaining		0.956
-Positive	18.35 (7.15-29.56)
-Negative	31.01 (23.48-38.55)
PD-L1 immunostaining		0.658
-Positive	16.39 (5.67-27.11)
-Negative	25.71 (15.48-35.93)
TCGA classification		<0.001
-EBV	7.85 (1.39-14.30)
-MSI	51.78 (38.59-64.98)
-GS	15.65 (6.41-24.89)
-CIN	30.26 (20.71-39.82)
ACRG classification		0.001
-MSI	51.78 (38.59-64.98)
-MSS/EMT	15.69 (6.82-24.56)
-MSS/P53-	26.24 (15.27-37.21)
-MSS/P53+	25.51 (15.74-35.28)
Integrated classification		<0.001
-EBV	7.85 (1.39-14.30)
-MSI	51.78 (38.59-64.98)
-E-cadherin aberrant	15.65 (6.41-24.89)
-P53 aberrant	27.74 (16.26-39.22)
-P53 normal	26.69 (16.26-37.13)