Correlation between Family RB1 Gene Pathogenic Variant with Clinical Features and Prognosis of Retinoblastoma under 5 Years Old

Table 4

Analysis of RB1 gene pathogenic variants and onset characteristics.

Onset characteristics		RB1 gene pathogenic variant cases (m)	% (m/n)	Statistics value ()
Age (mon)	40	19	47.5 (19/40)	4.607	0.019
0 ~ 12	13	3	18.6 (3/13)
12-36	23	13	56.5 (13/23)
4	4	3	75.0 (3/4)
Eye classification	40	19	47.5 (19/40)	10.119	0.002
Unilateral RB	21	5	23.8 (5/21)
Bilateral RB/trilaterall RB	19	14	76.2 (14/17)
Risk group	40	19	47.5 (19/40)	6.278	0.049
Low-risk (LR) group	29	12	41.4 (12/29)
Intermediate-risk (IR) group	6	2	33.3 (2/6)
High-risk group (HR)	5	5	100.0 (5/5)
Family genetic high-risk factors	40	19	47.5 (19/40)	5.647	0.021
Yes	10	8	80.0 (8/10)
No	30	11	36.7 (11/30)
Congenital developmental defects	40	19	47.5 (19/40)	0.005	0.731
Yes	2	1	50.0 (1/2)
No	38	18	47.4 (18/38)
Pathology grade of children with eye removal	23	9	39.1 (9/23)	0.059	0.582
Posterior optic nerve un infringed	16	6	37.5 (6/16)
Invasion of the posterior optic nerve and end of bulb	7	3	14.3 (3/7)

: 2 of 40 cases were trilateral RB and all had RB1 gene pathogenic variant.