Correlation between Family RB1 Gene Pathogenic Variant with Clinical Features and Prognosis of Retinoblastoma under 5 Years Old

Table 6

RB1 gene pathogenic variants and diagnosis of age and onset eye features in 40 RB patients.

Age group (months)	Number (% m/n)	RB1 gene pathogenic variant (% m/n)	Non-RB1 gene pathogenic variant (% m/n)
0-12 m	13 (32.5% 13/40)	23.1 (3/13)	76.9 (10/13)	0.122
Unilateral RB	6 (46.2% 6/13)	0.0 (0/6)	100.0 (6/6)
Bilateral/trilateral RB	7 (46.13% 7/13)	42.9 (3/7)	57.1 (4/7)
12-36 m	23 (57.5% 13/40)	56.5 (13/23)	43.5 (10/23)	0.027
Unilateral RB	14 (60.9% 14/23)	35.7 (5/14)	64.3 (9/14)
Bilateral/trilateral RB	9 (39.1% 9/23)	88.9 (8/9)	11.1 (1/9)
36-60 m	4 (10.0% 4/40)	75.0 (3/4)	25.0 (1/4)	0.250
Unilateral RB	1 (25.0% 1/4)	0.0 (0/1)	100.0 (1/1)
Bilateral/trilateral RB	3 (75.0% 3/4)	100.0 (3/3)	0.0 (0/3)