Research Article
Correlation between Family RB1 Gene Pathogenic Variant with Clinical Features and Prognosis of Retinoblastoma under 5 Years Old
Table 7
Types and RB1 genetic analysis of diagnosis of age and onset eye features in 40 RB patients.
| | Age group (months) | Number (% m/n) | Germline inheritance (% m/n) | RB1 gene pathogenic variant (% m/n) | Non-RB1 gene pathogenic variant (% m/n) | |
| | 0-12 m | 13 (32.5% 13/40) | 23.1 (3/13) | 7.7 (1/13) | 69.2 (9/13) | 0.049 | | Unilateral RB | 6 (46.2% 6/13) | 0.0 (0/6) | 0.0 (0/6) | 100.0 (6/6) | | Bilateral/trilateral RB | 7 (46.13% 7/13) | 42.9 (3/7) | 14.3 (1/7) | 42.8 (3/7) | | 12-36 m | 23 (57.5% 13/40) | 26.1 (6/23) | 30.4 (7/23) | 43.5 (10/23) | 0.025 | | Unilateral RB | 14 (60.9% 14/23) | 14.3 (2/14) | 21.4 (3/14) | 64.3 (9/14) | | Bilateral/trilateral RB | 9 (39.1% 9/23) | 44.4 (4/9) | 44.4 (4/9) | 11.2 (1/9) | | 36-60 m | 4 (10.0% 4/40) | 0.0 (0/4) | 75.0 (3/4) | 25.0 (1/4) | 0.250 | | Unilateral RB | 1 (25.0% 1/4) | 0.0 (0/1) | 0.0 (0/1) | 100.0 (1/1) | | Bilateral/trilateral RB | 3 (75.0% 3/4) | 0.0 (0/3) | 100.0 (3/3) | 0.0 (0/3) |
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