Overexpression of Pleckstrin Homology Domain-Containing Family A Member 4 Is Correlated with Poor Prognostic Outcomes and Immune Infiltration in Lower-Grade Glioma

Table 1

Correlation between PLEKHA4 expression and clinicopathologic factors in the TCGA cohort.

Characteristic	Low expression of PLEKHA4	High expression of PLEKHA4
	264	264
WHO grade, (%)			< 0.001
G2	143 (30.6%)	81 (17.3%)
G3	94 (20.1%)	149 (31.9%)
IDH status, (%)			< 0.001
WT	13 (2.5%)	84 (16%)
Mut	249 (47.4%)	179 (34.1%)
1p/19q codeletion, (%)			< 0.001
Codel	147 (27.8%)	24 (4.5%)
Noncodel	117 (22.2%)	240 (45.5%)
Age, (%)			0.433
< =40	137 (25.9%)	127 (24.1%)
> 40	127 (24.1%)	137 (25.9%)
Primary therapy outcome, (%)			0.002
PD	38 (8.3%)	72 (15.7%)
SD	78 (17%)	68 (14.8%)
PR	31 (6.8%)	33 (7.2%)
CR	80 (17.5%)	58 (12.7%)
Gender, (%)			0.484
Female	124 (23.5%)	115 (21.8%)
Male	140 (26.5%)	149 (28.2%)
Age, median (IQR)	40 (33, 52)	41 (32, 54.25)	0.575