Serum Sestrin2 Was Lower in Septic Shock Patients with Cardiomyopathy

Table 1

Comparison of demographic and disease data among combined septic cardiomyopathy group, non-septic cardiomyopathy group, and healthy controls group.

	Control ( = 67)	-value	SS ( = 188)	SS patients ( = 188)
				Non-SICM ( = 127)	SICM ( = 61)	-value
Age (years)	57 [46, 67]	< 0.01	65 [55, 72]	66 [55, 74]	65 [56, 72]	0.787
Sex (male%)	39 (58%)	0.670	115 (61%)	80 (63%)	35 (57%)	0.460
APACHEII	—	—	—	26 [19, 31]	26 [18, 32]	0.923
SOFA score	—	—	—	13 [10, 16]	13 [10, 17]	0.923
SBP (mmHg)	—	—	—	110 [97, 120]	96 [86, 120]	0.024
Hg (g/L)	—	—	—	101 ± 18	99 ± 20	0.627
Alb (g/L)	—	—	—	31 ± 6	30 ± 5	0.199
WBC count (×10^9/L)	—	—	—	11.6 [7.6, 17.1]	14 [8.1, 18.6]	0.280
PCT (ng/L)	—	—	—	11.2 [2.6, 28]	19 [4.3, 41.5]	0.069
Norepinephrine (μg/kg.min)	—	—	—	0.1 [0.03, 0.6]	0.4 [0.1, 1]	0.004
cTnI (mg/L)	—	—	—	0.03 [0.01, 0.24]	0.06 [0.02, 0.51]	0.071
NTproBNP (ng/L)	—	—	—	982 [524, 3727]	5040 [1765, 8920.5]	< 0.01
Sestrin2 (ng/mL)	5.8 [5.1, 6.6]	< 0.01	12.4 [7.9, 18.9]	14.6 [9.1, 19.2]	9.1 [7.3, 17.6]	0.043

Note. Controls: healthy controls group; SS: septic shock patients; no-SICM: non-septic cardiomyopathy group; SCIM: septic cardiomyopathy group; SBP: systolic blood pressure; Hg: hemoglobin; Alb: albumin.