Valsartan Regulates PI3K/AKT Pathways through lncRNA GASL1 to Improve Isoproterenol-Induced Heart Failure

Figure 1

Effect of VAL on cardiac function in rats with ISO-induced HF. (a–d) Results of cardiac function (LVSP, LVEDP, +dP/dtmax, and -dP/dtmax) of rats in different treatment groups (“” indicates that compared with the sham group, “^#” indicates that compared with the ISO group ). (e) The expression levels of lnc GASL1 in rat heart tissues (“” indicates that compared with the sham group, “^#” indicates that compared with the ISO group ). (f) Western blot bands and gray value analysis of PI3K, AKT, and p-AKT (“” indicates that compared with the sham group, “^#” indicates that compared with the ISO group ). (g) Western blot bands and gray value analysis of cleaved-caspase-3 (“” indicates that compared with the sham group, “^#” indicates that compared with the ISO group ).

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