The Correlation of HK2 Gene Expression with the Occurrence, Immune Cell Infiltration, and Prognosis of Renal Cell Carcinoma

Figure 2

Human renal cell carcinoma tissues and cell lines have elevated expression of hexokinase 2. (a) The expression of HK2 was significantly higher in tumor tissues in contrast with normal tissue samples. (b) The low-expression group has an expression level of HK2 lower than the mean value of ~4, and the high-expression group has higher expression levels than the mean values. (c) High expression of HK2 groups was shown in the T2 tumor stage and undifferentiated high-grade columns, whereas low-expression groups were found in the T1 tumor stage and differentiated low-grade RCC tumors. (d) mRNA and protein expression levels of HK2 in renal cancer and normal cell lines. (e) HK2 protein levels were also elevated in tumor cell lines in contrast with the normal cell line.

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