Development and Validation of a Liquid-Liquid Phase Separation-Related Gene Signature as Prognostic Biomarker for Low-Grade Gliomas

Table 1

The prognosis-related phase separation-related genes.

Predictor	Univariable Cox regression analysis				LASSO Cox coefficient	Multivariable stepwise Cox regression analysis
		HR	95% CI for HR	value			HR	95% CI for HR	value
ABL1	0.212	1.237	1.027-1.49	0.025	-0.001241	-0.376	0.686	0.457-1.031	0.07
AKAP8	0.451	1.571	1.16-2.126	0.003	0
AR	0.322	1.38	1.213-1.57	0	0.11761	0.171	1.187	1.006-1.399	0.042
CCNT1	0.219	1.245	1.038-1.494	0.018	0
CDK1	0.24	1.271	1.133-1.427	0	0.148498	0.319	1.376	1.179-1.607	0
CPLX1	-0.227	0.797	0.729-0.871	0	-0.035502
DAXX	0.323	1.381	1.02-1.871	0.037	-0.201314	-0.567	0.567	0.307-1.05	0.071
DNAJB1	0.232	1.261	1.009-1.574	0.041	0
ELN	0.227	1.254	1.081-1.455	0.003	0.077678	0.154	1.167	0.963-1.414	0.115
EN2	0.156	1.169	1.048-1.303	0.005	0.044444
G3BP1	0.236	1.266	1.068-1.5	0.006	0
GOLGA2	0.422	1.525	1.174-1.981	0.002	0
HNRNPA2B	0.259	0.259	1.043-1.61	0.019	0
HNRNPAB	0.35	1.419	1.117-1.804	0.004	0
HNRNPF	0.347	0.347	1.152-1.739	0.001	0
HNRNPH1	0.317	1.373	1.146-1.646	0.001	0
HTR1A	-0.122	0.885	0.828-0.946	0	-0.042494
KMT2D	0.293	1.341	1.122-1.602	0.001	0.120985	0.344	1.41	1.082-1.837	0.011
KPNA2	0.205	1.228	1.02-1.478	0.03	0
KPNB1	0.196	1.217	1.023-1.447	0.027	0
MLLT1	0.163	1.177	1.029-1.348	0.018	0
NUP98	0.283	1.327	1.049-1.68	0.018	0
PMEL	0.214	1.239	1.072-1.431	0.004	0
POU5F1	0.134	1.143	1.015-1.288	0.028	0.067597	0.117	1.124	0.976-1.294	0.105
PRNP	-0.155	0.856	0.75-0.978	0.022	0
PTBP1	0.594	1.811	1.344-2.44	0	0
RAD23B	0.234	1.264	1.012-1.578	0.039	0
SH3KBP1	0.416	1.516	1.18-1.946	0.001	0.098287	0.331	1.392	0.983-1.972	0.063
SNCB	-0.178	0.837	0.778-0.9	0	0
SOX2	0.169	1.184	1.016-1.379	0.03	0
SPOP	0.209	1.232	1.014-1.497	0.036	0
SYN1	-0.279	0.756	0.686-0.834	0	-0.13603	-0.274	0.76	0.676-0.854	0
SYN2	-0.188	0.828	0.754-0.91	0	0
TNPO1	0.194	1.214	1.027-1.436	0.023	0
USH1C	-0.154	0.857	0.796-0.922	0	-0.07669
WWTR1	0.232	1.261	1.102-1.443	0.001	0
YAP1	0.246	1.279	1.114-1.468	0	0

Abbreviations: HR: hazard ratio; CI: confidence interval; LASSO: least absolute shrinkage and selection operator.