Metabolic Profiling of Serum for Osteoarthritis Biomarkers

Table 3

Affected metabolic pathways in rabbit serum.

Pathway	RichFacor	KEGG.Name	KEGG.ID	value	Direction
ESI-
HIF-1 signaling pathway	1/15	Ascorbic acid	C00072	0.0049	Up
Valine, leucine, and isoleucine biosynthesis	1/23	L-(+)-valine	C00183	0.0074	Up
Pantothenate and CoA biosynthesis	1/28	L-(+)-valine	C00183	0.0091	Up
Mineral absorption	1/29	L-(+)-valine	C00183	0.0094	Up
Glutathione metabolism	1/38	Ascorbic acid	C00072	0.0123	Up
Vitamin digestion and absorption	1/39	Ascorbic acid	C00072	0.0126	Up
Valine, leucine, and isoleucine degradation	1/42	L-(+)-valine	C00183	0.0136	Up
Protein digestion and absorption	1/47	L-(+)-valine	C00183	0.0152	Up
Ascorbate and aldarate metabolism	1/49	Ascorbic acid	C00072	0.0158	Up
Aminoacyl-tRNA biosynthesis	1/52	L-(+)-valine	C00183	0.0168	Up
Phenylalanine metabolism	1/60	Benzoic acid	C00180	0.0193	Up
Tyrosine metabolism	1/78	Gentisic acid	C00628	0.0251	Down
ABC transporters	1/124	L-(+)-valine	C00183	0.0396	Up
Biosynthesis of amino acids	1/128	L-(+)-valine	C00183	0.0408	Up
2-Oxocarboxylic acid metabolism	1/134	L-(+)-valine	C00183	0.0427	Up
ESI+
Circadian entrainment	1/9	Melatonin	C01598	0.0111	Up
Vitamin B6 metabolism	1/28	4-pyridoxate	C00847	0.0343	Down