LTB4 Promotes Acute Lung Injury via Upregulating the PLC<i>ε</i>-1/TLR4/NF-<i>κ</i>B Pathway in One-Lung Ventilation

<div>LTB4 promotes OLV-induced ALI by activating the PLC<i>ε</i>-1/TLR4/NF-KB signaling pathway. (a–c) qRT-PCR validated expression of LTA4H, BLT1, and PLC<i>ε</i>-1 in control rats, OLV rats, PLC<i>ε</i>-1 knockdown rats, and okanin-treated rats. (d, e) Western blot examined expression of LTA4H, BLT1, and PLC<i>ε</i>-1 in control rats, OLV rats, PLC<i>ε</i>-1 knockdown rats, and okanin-treated rats. (f) ELISA examined LTB4 level in control rats, OLV rats, PLC<i>ε</i>-1 knockdown rats, and okanin-treated rats. 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Disease Markers

fig6

Figure 6

Figure 6: LTB4 Promotes Acute Lung Injury via Upregulating the PLC<i>ε</i>-1/TLR4/NF-<i>κ</i>B Pathway in One-Lung Ventilation 

Disease Markers

LTB4 Promotes Acute Lung Injury via Upregulating the PLCε-1/TLR4/NF-κB Pathway in One-Lung Ventilation

Figure 6