The Association between Serum Anion Gap and All-Cause Mortality in Cerebral Infarction Patients after Treatment with rtPA: A Retrospective Analysis

Table 3

Relationship between anion gap and all-cause mortality in different models.

Variable	Crude model		Model I		Model II		Model III
	HR (95% CLs)	value	HR (95% CLs)	value	HR (95% CLs)	value	HR (95% CLs)	value
Whole period all-cause mortality
Anion gap (median), mmol/L
≤14	1.0 (ref)	0.002	1.0 (ref)		1.0 (ref)		1.0 (ref)
>14	1.56 (1.18, 2.06)		1.62 (1.21, 2.15)	0.001	1.56 (1.16, 2.09)	0.003	1.47 (1.08, 2.02)	0.016
One-year all-cause mortality
Anion gap (median), mmol/L
≤14	1.0 (ref)		1.0 (ref)		1.0 (ref)		1.0 (ref)
>14	1.47 (1.08, 2.00)	0.014	1.61 (1.17, 2.22)	0.003	1.82 (1.29, 2.56)	0.001	2.18 (1.50, 3.16)	<0.001
Four-year all-cause mortality
Anion gap (median), mmol/L
≤14	1.0 (ref)		1.0 (ref)		1.0 (ref)		1.0 (ref)
>14	1.65 (1.24, 2.18)	0.001	1.77 (1.33, 2.36)	>0.001	1.68 (1.25, 2.25)	0.001	1.52 (1.10, 2.08)	0.01

Notes: the crude model adjusted for none; on the basis of crude model, model I adjusted for age, gender, ethnicity, and skin tone; on the basis of model I, model II adjusted for congestive heart failure, coronary atherosclerosis, diabetes, ESRD, AMI, hyperlipidemia, hypertension, and respiratory failure; on the basis of model II, model III adjusted for creatinine, INR, MCHC, MCH, platelet, RBC, RDW, and WBC. Abbreviations: AG: anion gap; CI: confidence interval; HR: hazard ratio; Ref: reference.