Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-<i>κ</i>B Signaling Pathway to Promote Calcific Aortic Valve Disease Development

<div>DEGs in stenosis and sclerosis samples were identified through bioinformatics. (a) Volcano plot of DEGs in stenosis and sclerosis samples. (b) Heatmap of DEGs in stenosis and sclerosis samples. (c) and (d) Bar graph of functional enrichment analysis performed through DAVID. Abbreviation: DEGs: differentially expressed genes.</div>

Disease Markers

fig1

Figure 1

Figure 1: Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-<i>κ</i>B Signaling Pathway to Promote Calcific Aortic Valve Disease Development 

Figure 1 | Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-κB Signaling Pathway to Promote Calcific Aortic Valve Disease Development 