Prognostic Value of HPV E6 and APOBEC3B in Upper Urinary Tract Urothelial Carcinoma

Table 2

Univariate and multivariate Cox regression analyses for DFS.

Variables	Univariate			Multivariate
	HR	CI 95%	value	HR	CI 95%	value
	1.285	0.720-2.293	0.397
Gender male vs. female	0.716	0.396-1.296	0.270
Smoking yes vs. no	0.946	0.522-1.712	0.854
LVI yes vs. no	2.103	1.102-4.015	0.024
T STAGE pTa + pT1VS.pT2 + pT3 + pT4	2.346	1.242-4.431	0.009
N STAGE pN0/Nx vs. pN+	3.241	1.144-9.182	0.027
Grade high vs. low	1.207	0.561-2.597	0.631
APOBEC3B	0.348	0.176-0.690	0.002	0.408	0.203-0.821	0.012
HPV E6	0.426	0.230-0.792	0.007