Relationship between Red Blood Cell Indices (MCV, MCH, and MCHC) and Major Adverse Cardiovascular Events in Anemic and Nonanemic Patients with Acute Coronary Syndrome
Table 2
Multivariate Cox regression analysis for MACEs of MCV, MCH, and MCHC.
Anemic group
Nonanemic group
Unadjusted
Unadjusted
Model 1
Model 2
HR
95% CI
value
HR
95% CI
value
HR
95% CI
value
HR
95% CI
value
MCV
Tertile 1
1.0 (ref)
1.0 (ref)
1.0 (ref)
1.0 (ref)
Tertile 2
0.605
0.192-1.907
0.391
1.075
0.464-2.489
0.866
1.127
0.479-2.648
0.785
1.253
0.521-3.011
0.615
Tertile 3
1.039
0.376-2.870
0.941
2.347
1.121-4.913
0.024
2.419
1.103-5.305
0.028
2.743
1.184-6.355
0.019
for trend
0.597
0.022
0.033
0.029
MCH
Tertile 1
1.0 (ref)
1.0 (ref)
1.0 (ref)
1.0 (ref)
Tertile 2
0.755
0.243-2.343
0.626
1.134
0.497-2.587
0.765
1.268
0.531-3.026
0.593
1.477
0.607-3.593
0.390
Tertile 3
1.204
0.417-3.473
0.732
2.626
1.249-5.520
0.011
3.522
1.475-8.410
0.005
4.530
1.808-11.348
0.001
for trend
0.688
0.010
0.004
0.001
MCHC
Tertile 1
1.0 (ref)
1.0 (ref)
1.0 (ref)
1.0 (ref)
Tertile 2
1.694
0.585-4.906
0.332
0.925
0.471-1.815
0.820
0.895
0.441-1.819
0.760
0.871
0.311-2.441
0.793
Tertile 3
1.148
0.370-3.562
0.811
0.812
0.384-1.719
0.586
0.815
0.374-1.772
0.605
0.762
0.135-4.288
0.758
for trend
0.591
0.862
0.873
0.953
Model 1: adjusted for age, male, diabetes, hypertension, smoking, and LVEF. Model 2: further adjusted for RBC, hemoglobin, HCT, and RDW-CV. 95% CI: 95% confidence interval; HCT: hematocrit value; HR: hazard ratio; LVEF: left ventricular ejection fraction; MACEs: major adverse cardiovascular events; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean corpuscular volume; RBC: red blood cell; RDW-CV: red cell volume distribution width-coefficient of variation; ref: reference group.