Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-β in Spontaneously Hypertensive Rats

Figure 4

Silencing of TLR4 reduced mRNA expression of NLRP3 and TGF-β in vivo. Relative mRNA expression of TLR4, NLRP3, TGF-β, and collagen I normalized to GAPDH in left atrial tissue (a–d). All aforementioned data are represented as (). Statistical analyses: the values were evaluated by ANOVA, followed by a post hoc Tukey’s test. , , and versus the control; ^#, ^##, and ^### versus the SHR group; ^&, ^&&, and ^&&& versus the SHR+vehicle group; significantly different as indicated.

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