SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis

Figure 1

SPTBN2 in PTC samples was highly upregulated compared with that in nontumor tissues. (a) RNA-seq dataset containing 79 PTC tissue samples and paired adjacent nontumor tissue samples (). (b) ROC for the expression of SPTBN2 in the RNA-seq cohort () (). (c) TCGA dataset containing 502 PTC tissues and 58 normal thyroid tissues (). (d) ROC for the expression of SPTBN2 in TCGA cohort () (). (e) Local validated cohort containing 48 PTC tissue samples and paired adjacent nontumor tissue samples (). (f) ROC for the expression of SPTBN2 in the local validated cohort () (). The optimal cutoff value of SPTBN2 expression was determined by maximizing the Youden index value. . The data are presented as the (three independent experiments). .

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