Activated Partial Thromboplastin Time and Mortality in Coronary Artery Bypass Grafting Patients

Table 4

Univariate and multivariate Cox regression analyses of APTT for 4-year mortality in study patients before and after PSM.

	Univariate		Multivariate
			Model 1		Model 2
	HR (95% CI)		HR (95% CI)		HR (95% CI)
Before PSM
APTT	2.29 (1.89-2.77)	<0.001	1.81 (1.49-2.21)	<0.001	1.42 (1.16-1.74)	0.001
Gender	1.40 (1.14-1.71)	0.001	1.03 (0.84-1.27)	0.756	1.06 (0.86-1.30)	0.598
Age	1.07 (1.06-1.08)	<0.001	1.06 (1.05-1.07)	<0.001	1.06 (1.05-1.07)	<0.001
Hypertension	0.67 (0.55-0.81)	<0.001			0.67 (0.54-0.82)	<0.001
DM	1.12 (0.92-1.36)	0.249
Peripheral vascular disease	1.90 (1.51-2.39)	<0.001			1.32 (1.04-1.67)	0.024
MI	1.20 (0.96-1.51)	0.113
CHF	2.87 (2.37-3.47)	<0.001			1.80 (1.47-2.20)	<0.001
Chronic pulmonary disease	1.68 (1.32-2.13)	<0.001			1.46 (1.15-1.86)	0.002
Renal failure	2.78 (2.15-3.59)	<0.001			1.45 (1.07-1.97)	0.017
Liver disease	1.87 (1.03-3.40)	0.04			2.30 (1.26-4.21)	0.007
Obesity	0.63 (0.36-1.09)	0.101
Mechanical ventilation	0.69 (0.45-1.08)	0.103
CRRT	22.35 (16.04-31.14)	<0.001			13.7 (9.20-20.39)	<0.001
Vasopressor use	1.10 (0.83-1.46)	0.508
After PSM
APTT	1.49 (1.16-1.91)	0.002	1.52 (1.19-1.95)	0.001	1.47 (1.14-1.89)	0.003
Gender	1.14 (0.89-1.47)	0.307	1.00 (0.77-1.29)	0.971	1.03 (0.80-1.33)	0.839
Age	1.05 (1.04-1.07)	<0.001	1.05 (1.04-1.07)	<0.001	1.06 (1.04-1.07)	<0.001
Hypertension	0.75 (0.59-0.97)	0.029			0.66 (0.50-0.85)	0.002
DM	1.25 (0.97-1.61)	0.083
Peripheral vascular disease	1.64 (1.22-2.20)	0.001			1.4 (1.04-1.89)	0.025
MI	1.06 (0.79-1.42)	0.691
CHF	2.31 (1.81-2.94)	<0.001			1.77 (1.37-2.28)	<0.001
Chronic pulmonary disease	1.35 (0.99-1.85)	0.061			1.21 (0.88-1.66)	0.248
Renal failure	2.33 (1.69-3.21)	<0.001			1.53 (1.06-2.21)	0.025
Liver disease	1.42 (0.70-2.87)	0.327			1.98 (0.97-4.04)	0.059
Obesity	1.07 (0.57-2.02)	0.825
Mechanical ventilation	0.57 (0.35-0.95)	0.031
CRRT	15.54 (10.06-23.99)	<0.001			14.51 (8.82-23.89)	<0.001
Vasopressor use	1.22 (0.85-1.76)	0.279