Altered Functional Connectivity in Pain-Related Brain Regions and Its Correlation with Pain Duration in Bone Metastasis with Cancer Pain

Table 3

Functional connectivity differences of the pain-related brain regions in three groups.

	ANCOVA		Post hoc test
Brain region	() value	value	() value	value
DLPFC (R)—ACC (R)	3.297	0.043	−2.400^a	0.019^a
ACC (L)—AMY (L)	7.394	0.025	2.661^b	0.023^b
SII (L)—SII (R)	5.769	0.005	2.003^b	0.049^b
			−3.377^c	0.001^c
ACC (L)—ACC (R)	6.446	0.003	−3.594^c	0.001^c
THA (L)—THA (R)	4.493	0.014	−2.980^c	0.004^c

means results of nonparametric test; ^a; ^b; ^c. Abbreviations: CP+: lung cancer patients with bone metastases suffering from cancer pain; CP−: lung cancer patients without pain-related complaints; HC: health controls; ANCOVA: analysis of covariance; DLPFC: dorsolateral prefrontal cortex; ACC: anterior cingulate gyrus; AMY: amygdala; SII: secondary somatosensory cortex; THA: thalamus; R: right; L: left.