Transient Receptor Potential Vanilloid-1 (TRPV1) Alleviates Hepatic Fibrosis via TGF-β Signaling

Figure 1

TRPV1 modulates CCl₄-induced hepatic fibrosis in mice, and its expression is downregulated in human liver fibrosis. (a) TRPV1 protein expression in TRPV1^−/− mice was measured through Western blot analysis. (b) Morphology of whole livers and H&E-stained liver sections (400x magnification) from the four CCl₄-induced hepatic fibrosis models (WT with capsaicin intraperitoneal injection, WT with DMSO intraperitoneal injection, WT, TRPV1^−/−, all under CCl4 treatment). (c) Pathological morphology of the four animal models was shown by picro-sirius red staining. (d) Quantitative analysis of the fibrosis area. Data are presented as ( mice). . (e) Representative immunohistochemistry images of TRPV1 expression in normal control liver and liver fibrosis. (f) The semiquantitative levels of TRPV1 expression by immunohistochemistry in liver paraffin sections from 10 normal control and 40 liver fibrosis patients. . Data are presented as .

(a)

(b)

(c)

(d)

(e)

(f)