Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis

<div>FOXA1 enhances the proliferation of cancer cells in vitro and in vivo. (a) The growth rates of the FOXA1-overexpressing and no-load Huh7 and L02 cell lines were compared. (b) A colony formation assay was performed with Huh7 and L02 cells. (c) The results from the statistical analysis related to colony formation are shown. (d) The tumor volumes were measured during their growth process using a Vernier caliper and calculated with the formula <span class="nowrap"><svg height="15.2688pt" id="M52" style="vertical-align:-3.403299pt" version="1.1" viewbox="-0.0498162 -11.8655 102.355 15.2688" width="102.355pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path d="M238 0V26C174 32 166 38 166 104V712C132 700 70 683 18 677V653C81 647 87 645 87 577V104C87 38 78 32 15 26V0H238Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.787,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 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Disease Markers

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Figure 7

Figure 7: Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis 