Integrated Bioinformatics-Based Identification of Ferroptosis-Related Genes in Carotid Atherosclerosis

Table 2

Functional and pathway enrichment analyses for module genes. The top 3 terms were selected based upon the counts of genes enriched and then sorted by .adjust.

Term	Description	Count	P-value	Adj. value	Genes	Gene ratio	Bg ratio
Biological processes
GO:0006979	Response to oxidative stress	10	1.916459e-09	3.047170e-06	HMOX1, IDH1, CYBB, ALOX5, TNFAIP3, NCF2, NOX4, ANGPTL7, EGFR, PRKAA2	10/32	444/18862
GO:0062197	Cellular response to chemical stress	9	4.204559e-09	3.342625e-06	HMOX1, CYBB, ALOX5, TNFAIP3, NCF2, NOX4, CAV1, EGFR, PRKAA2	9/32	347/18862
GO:0072593	Reactive oxygen species metabolic process	8	1.694471e-08	8.980695e-06	CYBB, ALOX5, NCF2, DDIT4, IL1B, NOX4, CAV1, EGFR	8/32	281/18862
Cellular component
GO:0043020	NADPH oxidase	3	7.901755e-07	9.087018e-05	CYBB, NCF2, NOX4	3/31	12/19520
GO:0030139	Endocytic vesicle	6	7.618949e-06	4.380896e-04	DPP4, CYBB, NCF2, GRIA3, CAV1, EGFR	6/31	307/19520
GO:0101002	Fcolin-1-rich	4	2.011593e-04	7.711105e-03	IDH1, CTSB, ALOX5, SLC2A3	4/31	185/19520
Molecular functions
GO:0016175	Superoxide-generating NAD(P)H oxidase activity	3	7.890044e-07	1.222957e-04	CYBB, NCF2, NOX4	3/32	11/18337
GO:0050664	Oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	3	2.661993e-06	2.063044e-04	CYBB, NCF2, NOX4	3/32	16/18337
GO:0005506	Iron ion binding	4	1.294260e-04	6.687010e-03	FTL, ALOX5, SCD, CDO1	4/32	150/18337
KEGG pathway
Hsa04216	Ferroptosis	5	2.091572e-08	1.882415e-06	HMOX1, CYBB, FTL, SAT1, TFRC	5/18	41/8113
Hsa04621	NOD-like receptor signaling pathway	5	3.830373e-05	1.723668e-03	CYBB, CTSB, TNFAIP3, IL1B, CXCL2	5/18	184/8113
Hsa04217	Necroptosis	4	3.507860e-04	1.052358e-02	CYBB, FTL, TNFAIP3, IL1B	4/18	159/8113