Research Article
The Value of SII in Predicting the Mortality of Patients with Heart Failure
Table 1
Baseline characteristics of the study population by SII.
| | Group 1 | Group 2 | Group 3 | p value | SII≤966
n=3032 | 966<SII≤2327
n=3036 | SII>2327
n=3039 |
| | Characteristic | | | | | | Age(years) | 74(62-83) | 75(64-84) | 77(66-84) | <0.001 | | Gender | | | | <0.001 | | Male | 1682(55.5%) | 1578(52.0%) | 1517(49.9%) | | | Female | 1350(44.5%) | 1458(48.0%) | 1522(50.1%) | | | SOFA (0-24) | 4(2-6) | 4(2-6) | 4(2-6) | 0.212 | | Ethnicity | | | | <0.001 | | White | 2147(70.8%) | 2267(74.7%) | 2331(76.7%) | | | Asian | 58(1.9%) | 47(1.5%) | 57(1.9%) | | | Black | 409(13.5%) | 243(8.0%) | 186(6.1%) | | | Hispanic/Latino | 92(3.0%) | 70(2.3%) | 61(2.0%) | | | Other | 326(10.8%) | 409(13.5%) | 404(13.3%) | | | Marital type | | | | <0.001 | | Divorced/separated | 323(10.7%) | 377(12.4%) | 346(11.4%) | | | Married | 1411(46.5%) | 1337(44.0%) | 1421(46.8%) | | | Single | 632(20.8%) | 574(18.9%) | 508(16.7%) | | | Widowed | 650(21.4%) | 720(23.7%) | 730(24.0%) | | | Other | 16(0.5%) | 28(0.9%) | 34(1.1%) | | | Vital sign | | | | | | Heartrate(/min) | 82.32(72.35-93.38) | 83.17(72.65-94.13) | 85.73(75.12-96.79) | <0.001 | | Systolic pressure(mmHg) | 113.67(104.72-125.96) | 114.97(104.86-126.69) | 114.25(104.59-127.56) | 0.264 | | Diastolic pressure(mmHg) | 57.12(50.85-63.93) | 56.83(50.73-63.68) | 56.33(50.34-63.02) | 0.019 | | Respiratory rates(/min) | 18.67(16.36-21.31) | 19.01(16.83-21.76) | 19.69(17.04-22.77) | <0.001 | | Temperature(°C) | 36.74(36.37-37.10) | 36.72(36.36-37.11) | 36.72(36.33-37.14) | 0.467 | | SpO2(%) | 97.37(95.99-98.57) | 97.18(95.79-98.44) | 97.13(95.64-98.45) | <0.001 | | Comorbidities | | | | | | infection | 1359(44.8%) | 1632(53.8%) | 1879(61.8%) | 0.001 | | diabetes | 1052(34.7%) | 1187(39.1%) | 1076(35.4%) | 0.001 | | dyslipidemia | 770(25.4%) | 756(24.9%) | 657(21.6%) | 0.001 | | hypertension | 622(20.5%) | 644(21.2%) | 620(21.1%) | 0.781 | | chronic pulmonary | 654(21.6%) | 759(25.0%) | 938(30.9%) | <0.001 | | pulmonary circulation | 149(4.9%) | 191(6.3%) | 204(6.7%) | 0.008 | | cardiac arrhythmias | 716(23.6%) | 868(28.6%) | 1042(34.3%) | <0.001 | | valvular disease | 319(10.5%) | 358(11.8%) | 359(11.8%) | 0.193 | | peripheral vascular | 336(11.1%) | 378(12.5%) | 379(12.5%) | 0.162 | | cerebral ischemic | 131(4.3%) | 121(4.0%) | 141(4.6%) | 0.455 | | renal failure | 747(24.6%) | 788(26.0%) | 773(25.4%) | 0.493 | | liver disease | 224(7.4%) | 124(4.1%) | 82(2.7%) | <0.001 | | obesity | 191(6.3%) | 230(7.6%) | 143(4.7%) | <0.001 | | Primary disease | | | | | | rheumatoid heart disease | 10(0.33%) | 8(0.26%) | 4(0.13%) | 0.277 | | pulmonary heart disease | 405(13.36%) | 405(13.33%) | 366(12.04%) | 0.216 | | coronary heart disease | 1509(49.77%) | 1487(48.99%) | 1358(44.69%) | <0.001 | | The type of heart failure | | | | | | HFrEF | 859(28.33%) | 881(29.02%) | 784(25.80%) | | | HFpEF | 764(25.20%) | 829(27.31%) | 838(27.57%) | | | unknown | 1409(46.47%) | 1326(43.68%) | 1417(46.63%) | | | length of hospital stay(day) | 8.28(5.13-13.83) | 8.85(5.20-14.46) | 9.31(5.80-16.64) | <0.001 | | length of ICU stay(day) | 2.68(1.35-5.00) | 2.86(1.44-5.50) | 3.10(1.72-6.72) | <0.001 | | Laboratory Results | | | | | | anion gap(mmol/L) | 15.00(13.00-18.00) | 16.00(13.00-18.00) | 16.00(14.00-19.00) | <0.001 | | creatinine(mg/dL) | 1.30(0.90-2.00) | 1.29(1.00-2.20) | 1.40(0.90-2.20) | 0.012 | | BUN(mg/dL) | 27.00(18.00-43.00) | 29.00(20.00-48.00) | 31.00(21.00-50.00) | <0.001 | | chloride(mmol/L) | 106.00(102.00-110.00) | 106(101-110) | 105(101-109) | <0.001 | | glucose(mg/dL) | 163(128-205) | 164.00(128.00-210.00) | 165.00(129.00-214.00) | 0.152 | | hemoglobin(mg/dL) | 9.70(8.40-11.20) | 9.90(8.60-11.30) | 9.90(8.60-11.10) | 0.014 | | INR | 1.50(1.20-1.90) | 1.50(1.20-1.90) | 1.50(1.20-1.90) | 0.293 | | PT(seconds) | 15.70(13.80-18.49) | 15.50(13.70-18.49) | 15.60(13.70--18.49) | 0.203 | | sodium(mmol/L) | 140.00(138.00-142.00) | 140.00(137.00-142.00) | 140.00(138.00-143.00) | 0.774 | | potassium(mmol/L) | 4.60(4.20-5.20) | 4.60(4.20-5.20) | 4.60(4.10-5.20) | 0.043 | | 30-day mortality | 480(15.8%) | 565(18.6%) | 777(25.6%) | <0.001 | | 60-day mortality | 615(20.3%) | 730(24.0%) | 974(32.1%) | <0.001 | | 180-day mortality | 821(27.1%) | 986(32.5%) | 1254(41.3%) | <0.001 | | 365-day mortality | 998(32.9%) | 1183(39.0%) | 1444(47.5%) | <0.001 |
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INR: international normalized ratio; PT: prothrombin time; BUN: blood urea nitrogen; HFrEF: heart failure with reduced ejection fraction; HFpEF: heart failure with preserved ejection fraction.
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