Prognostic and Clinical Significance of Aspartate Aminotransferase-to-Lymphocyte Ratio Index in Individuals with Liver Cancer: A Meta-Analysis

Table 2

Subgroup analysis of pooled HRs and 95% CIs between ALRI and OS and PFS in hepatocellular carcinoma.

Variables	No. of studies	No. of patients	Effects model	HR (95% CI)		Heterogeneity
						^2 (%)
OS
Total	11	3914	Random	1.53 (1.25-1.82)	<0.001	80.4	<0.001
Treatment
Surgical resection	8	3218	Random	1.49 (1.17-1.81)	<0.001	82.7	<0.001
TACE	2	267	Random	2.20 (1.19-3.22)	<0.001	0	0.940
Palliative treatments	1	429	_		0.004	_	_
Staging criteria
AJCC/NA	6	1960	Random	1.60 (1.38-1.81)	<0.001	0	0.823
BCLC	5	2060	Random	1.56 (1.20-1.91)	<0.001	43.3	0.133
Milan criteria	1	241	_	1.02 (1.01-1.02)	<0.001	_	_
Sample size
<230	4	664	Random	1.82 (1.29-2.34)	<0.001	0	0.701
≥230	7	3250	Random	1.45 (1.14-1.76)	<0.001	85.2	<0.001
Cut-off value of ALRI
<26	5	1534	Random	1.51 (1.21-1.80)	<0.001	31.4	0.212
≥26	6	2380	Random	1.54 (1.12-1.96)	<0.001	83.3	<0.001
Cut-off selection
ROC analysis	8	2501	Random	1.49 (1.31-1.68)	<0.001	0	0.441
R software	1	189	_	2.18 (1.30-3.65)	0.003	_	_
Mean value	1	241	_	1.02 (1.01-1.02)	<0.001	_	_
X-tile	1	983	_	1.76 (1.42-2.17)	<0.001
NOS score
<8	2	612	Random	1.24 (0.73-1.76)	<0.001	84	0.012
≥8	9	3302	Random	1.58 (1.37-1.78)	<0.001	16.3	0.298
PFS
Total	7	2899	Random	1.36 (1.10-1.63)	<0.001	81.8	<0.001
Treatment
Surgical resection	6	2821	Random	1.35 (1.08-1.61)	<0.001	84	<0.001
TACE	1	78	_	2.21 (1.04-4.71)	0.040	_	_
Staging criteria
NA	2	787	Random	1.60 (1.31-1.89)	<0.001	0	0.521
BCLC	4	1871	Random	1.37 (1.18-1.55)	<0.001	0	0.651
Milan criteria	1	241	_	1.01 (1.01-1.02)	<0.001	_	_
Sample size
<230	1	78	_	2.21 (1.04-4.71)	0.040	_	_
≥230	6	2821	Random	1.35 (1.08-1.61)	<0.001	84	<0.001
Cut-off value of ALRI
<26	4	1328	Random	1.48 (1.21-1.74)	<0.001	18.7	0.297
≥26	3	1571	Random	1.24 (0.92-1.57)	<0.001	85.5	0.001
Cut-off selection
ROC analysis	5	1675	Random	1.46 (1.26-1.66)	<0.001	0	0.448
Mean value	1	241	_	1.01 (1.01-1.02)	<0.001	_	_
X-tile	1	983	_	1.39 (1.17-1.65)	<0.001	_	_
NOS score
<8	2	612	Random	1.22 (0.73-1.70)	<0.001	82.9	0.016
≥8	5	1524	Random	1.42 (1.25-1.58)	<0.001	0	0.443