Alteration in the Immune Microenvironment Based on APC Status in MSS/pMMR Colon Cancer

Figure 1

Genomic landscape and clinicopathological findings in COAD samples, based on APC status in the cohort retrieved from TCGA (The Cancer Genome Atlas). (a) Frequency and type of mutations in the top 30 COAD-associated genes. Genes were sorted according to the frequency of mutations. (b) Interactions among mutations in the top 25 genes in COAD. (c) Summary of frequency and classification of mutations in the top 10 COAD-associated genes. (d) Summary of frequency and classification of mutations in the top 10 in APC-mt/MSS COAD-associated genes. (e) Summary of frequency and classification of mutations in the top 10 genes in APC-wt/MSS COAD-associated genes.

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