Alteration in the Immune Microenvironment Based on APC Status in MSS/pMMR Colon Cancer

<div>Immune score, stromal score, and TMB are associated with APC mutation status. (a, b) PRF1 and GZMA were significantly higher expression in APC-wt/MSS than APC-mt/MSS colon cancer. (c–e) Expression of CTLA4, PD-1, and PD-L1 in MSS/pMMR colon cancer with different APC gene subtypes. (f–h) Distribution of ESTIMATE score, immune score, and stromal score for APC-wt and APC-mt MSS/pMMR colon cancer. 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Disease Markers

fig2

Figure 2

Figure 2: Alteration in the Immune Microenvironment Based on APC Status in MSS/pMMR Colon Cancer 