Alteration in the Immune Microenvironment Based on APC Status in MSS/pMMR Colon Cancer

Figure 4

Genomic landscape and gene set enrichment analysis of the COAD samples, based on APC status in the cohort retrieved from TCGA (The Cancer Genome Atlas). (a) The immunity and cancer pathways that are significantly enriched in APC-wt/MSS COAD patients, compared with those in APC-mt/MSS COAD patients. (b, c) Gene Ontology (GO) analysis of the immune-related DEGs. Circular plot of GO pathways enrich in APC-wt/MSS samples. GO pathways cluster distribution. (d, e) GO analysis of the immune-related DEGs. Immune-related DEGs in the significantly enriched immunologic and cancer biological processes. (f, g) KEGG analysis of immune-related DEGs.

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