[Retracted] Calycosin Inhibits the Malignant Behaviors of Lung Adenocarcinoma Cells by Regulating the circ_0001946/miR-21/GPD1L/HIF-1α Signaling Axis

Figure 5

miR-21 regulates the level of HIF-1α through GPD1L. (a, b) The expression of HIF-1α in A549 and H1299 treated by different concentrations of calycosin detected by qRT-PCR, vs. control. (c, d) The expression of HIF-1α after knockdown of miR-21 or simultaneous knockdown of miR-21 and GPD1L (miR-21 inhibitor+si-GPD1L) in A549 and H1299 cells detected by qRT-PCR. (e, f) The protein expression of HIF-1α after knockdown of miR-21 or simultaneous knockdown of miR-21 and GPD1L (miR-21+si-GPD1L) in A549 and H1299 cells detected by western blot. (g) The correlation between GPD1L and HIF-1α expression in LUAD tissues analyzed by Pearson correlation analysis, vs. inhibitor and ^##vs. miR-21 inhibitor.

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