Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway

<div>Deguelin inhibits migration and invasion of NSCLC. (a and c) The cell scratch assay for A549 and PC9 cell migration after cells were transfected by PTEN-siR/overexpression, KLF4-siR/overexpression, and deguelin (25 <i>μ</i>M), respectively. The migration area was counted. (b and d) The cell invasion assay for A549 and PC9 cells after cells were transfected by PTEN-siR/overexpression, KLF4-siR/overexpression, and deguelin (25 <i>μ</i>M), respectively. The numbers of invasion cells were counted. Scale bar represents 100 <i>μ</i>m. All experiments were repeated at least in triplicate. 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Disease Markers

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Figure 3

Figure 3: Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway 