Characteristics of HBV Novel Serum Markers across Distinct Phases in Treatment-Naïve Chronic HBV-Infected Patients

Figure 3

The transcriptional efficiency of cccDNA and the reverse transcription efficiency of pgRNA across distinct disease phases. The transcriptional efficiency of cccDNA was determined by the ratio of serum HBV RNA (a), HBV DNA (b), HBcrAg (c), and HBsAg (d) to intrahepatic cccDNA. The reverse transcription efficiency of HBV pgRNA represented as a ratio of serum HBV RNA to HBV DNA was inversely related (e). The ratio of serum HBV DNA: (HBV DNA + HBV RNA) to assess the reverse transcriptional efficiency of pgRNA (f). Abbreviations: IT: immune-tolerant phase; IC: immune-clearance phases; LR: low-replicated phase; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HBcrAg: hepatitis B core-related antigen; cccDNA: covalently closed circular DNA; n: number of cases; ; ; ; ; ns, .

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