Disease Markers

Research Article

Characteristics of HBV Novel Serum Markers across Distinct Phases in Treatment-Naïve Chronic HBV-Infected Patients

Table 2

Univariate and multivariate logistic regression analysis of liver inflammation related indicators.


	METAVIR, inflammatory activity (grading)		Univariable	Multivariable
	Grading score< 2 ( = 91)	Grading score ≥ 2 ( = 20)	-value	OR (95% CI)	-value

Gender, male, (%)	57 (62.64)	11 (55.00)	0.703
Age, years	35 (29, 42)	35 (27, 45)	0.905
ALT, U/L	33 (20, 55)	278 (57, 657)	< 0.001	1.008 (0.997, 1.020)	0.154
AST, U/L	27 (21, 34)	113 (45, 440)	< 0.001	1.004 (0.986, 1.022)	0.685
HBsAg, IU/mL	15299 (1439, 49212)	6587 (1709, 22416)	0.234
HBeAg, COI	988.70 (0.11, 1786)	691.00 (9.78, 1482.50)	0.851
HBV DNA, log₁₀ IU/mL	7.46 (3.04, 9.00)	7.72 (6.48, 8.78)	0.283
HBV RNA, copies/mL	5.69 (1, 6.82)	6.03 (4.36, 6.40)	0.504
HBcrAg, log₁₀ U/mL	8.21 (3.04, 8.91)	8.04 (6.70, 8.50)	0.676
Anti-HBc, log₁₀ IU/mL	3.82 (3.15, 4.16)	4.27 (3.88, 4.46)	< 0.001	2.231 (0.605, 5.19)	0.273
Intrahepatic tDNA, log₁₀ copies/cells	7.42 (4.99, 7.98)	7.03 (6.29, 7.37)	0.878
Intrahepatic cccDNA, log₁₀ copies/cells	5.47 (3.85, 6.52)	5.59 (5.02, 6.24)	0.857

Abbreviations: ALT: alanine aminotransferase; AST: aspartate aminotransferase; cccDNA: covalently closed circular DNA; HBV: hepatitis B virus; HBeAg: hepatitis B e antigen; HBsAg: hepatitis B surface antigen; HBcrAg: hepatitis B core-related antigen; Anti-HBc: hepatitis B core antibody; tDNA: total DNA.