Association between Phenotypic Age and Mortality in Patients with Multivessel Coronary Artery Disease

Table 2

Associations between PhenoAge, PhenoAgeAccel, and all-cause mortality on follow-up.

Variable	HR (95% CI)
	Model 1^a	Model 2^b	Model 3^c
PhenoAge (per year)	1.05 (1.02, 1.08)	1.06 (1.03, 1.09)	1.04 (1.01, 1.08)
PhenoAge (per 10 years)	1.63 (1.27, 2.11)	1.74 (1.34, 2.27)	1.51 (1.10, 2.08)
PhenoAgeAccel subgroups
Negative	Reference	Reference	Reference
Positive	2.29 (1.38, 3.81)	2.58 (1.51, 4.41)	2.08 (1.14, 3.80)

Results are based on COX regression analysis. HR: hazard ratio; PhenoAge: phenotypic age; PhenoAgeAccel: phenotypic age acceleration. ^aModel 1 adjusted for chronological age. ^bModel 2 additionally adjusted for lesion number, disease count, and revascularization. ^cModel 3 additionally adjusted for other traditional cardiovascular risk factors, including gender, smoking, drinking, body mass index, serum uric acid, creatine kinase, creatine phosphokinase isoenzyme, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and N-terminal probrain natriuretic peptide. ⁺; ; ; .