miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction

<div>miR-657 upregulates EMT marker expression and promotes increased invasiveness in NSCLC cells. (a–c) The invasiveness of NCI-H1650 and A549 cells transfected with miR-657 mimic, inhibitor, or correspondent NC control constructs was assessed using Transwell invasion assay (200x). (d) Western blotting was employed for the evaluation of N-cadherin, E-cadherin, Vimentin, Slug, and Snail protein levels in A549 and NCI-H1650 cells transfected as indicated. 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Disease Markers

fig3

Figure 3

Figure 3: miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction 