miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction

<div>miR-657 regulates NSCLC cell malignancy in an SRCIN1-dependent manner. A549 and NCI-H1650 cells were transfected with a miR-657 inhibitor with or without shSRCIN1. (a) Western blotting was used for measuring SRCIN1 protein expressions in the indicated cell lines. (b) NCI-H1650 and A549 cell viability was appraised at 24, 48, and 72 h. (c and d) The proliferation of NCI-H1650 and A549 cells was appraised via EdU assessment. (e and f) The invasion of A549 and NCI-H1650 cells was assessed in a Transwell assessment. (g) Western blotting was employed to measure N-cadherin, E-cadherin, Vimentin, and Slug protein levels in NSCLC cell lines transfected as indicated, with GAPDH serving as a loading control. 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Disease Markers

fig7

Figure 7

Figure 7: miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction 